Kenichi Sakamoto, MD, PhDAssistant Professor

    125 Paterson Street, Room 7120
    New Brunswick, NJ 08901
    Email: Kenichi.sakamoto[at]


    • University of Tokyo, Bachelor of veterinary medicine
    • School of Medicine, Chiba University (MD)
    • Graduate School of Medicine, Chiba University (PhD)
    • Post-Doctoral Fellowship: Icahn School of Medicine at Mount Sinai 2018-2020

    Honors & Awards

    • The 50th European Association for the Study of Diabetes (EASD) Travel Grant Award, Vienna, Austria, 2014
    • The 51th European Association for the Study of Diabetes (EASD) Travel Grant Award, Stockholm, Sweden, 2015
    • Young Investigators Award. The 54th Annual Meeting of the Japanese Society of Molecular Medicine, Tokyo, Japan, 2017
    • Young Investigators Award. The 91th Annual Meeting of the Japan Endocrine Society, Miyazaki, Japan, 2018
    • Featured Oral Presentation. Icahn School of Medicine at Mount Sinai Department of Medicine Research Day, New York, U.S.A, 2019
    • Selected Oral Presentation. 4th Annual NYC Regional Obesity Forum, New York, U.S.A, 2019
    • Outstanding abstract award, travel grant. Endocrine Society’s Annual Meeting, ENDO 2020, San Francisco, U.S.A. (the meeting was canceled due to COVID-19), 2020
    • Selected Oral Presentation. The NYC regional Diabetes research symposium, New York, U.S.A. (the meeting was canceled due to COVID-19), 2020


    • Medical Doctor, Japan
    • Board Certified Member of the Japanese Society of Internal Medicine
    • Board Certified Diabetologist, Japan
    • Board Certified Endocrinologist, Japan

    Short Biography

    I’m an endocrinologist and I’m highly motivated by the need to improve diabetes which guides the basic science research that I feel is necessary to make significant strides in advancing our understanding of the pathogenesis of diabetes and obesity.

    I joined the Buettner lab in 2018 to obtain training in the integrated physiology of obesity and diabetes.

    There are 2 major projects that I am involved in besides a number of collaborations.

    First, characterize the role of the sympathetic nerve system in regulating peripheral metabolism and diabetes pathogenesis. To this end, we have developed innovative mice models, the peripherally restricted tyrosine hydroxylase knock-out mice (Figure), to study the role of adrenergic signaling in metabolic control.

    Second, to develop new approaches to monitor autonomic nervous system activity and adrenergic signaling in vivo in real-time. To this end, I adapted the new scientific techniques to monitor neurotransmitter sensing using cell-based systems and two-photon microscopy.

    Figure. Mouse model of peripherally restricted catecholamine depletionGenetic strategy of generation of THΔper mice by crossing mice flox for tyrosine hydroxylase (TH) with mice that express Cre under the control of tamoxifen inducible Rosa26 promotor (A). Owing to poor Cre expression in the CNS, the deletion of TH does not occur in the CNS but in all peripheral tissues (B). Catecholamine levels in peripheral tissues (C). *P < 0.05; **P < 0.01