We study the role brain in metabolic regulation and diabetes and how metabolic controls affect the brain.
Our lab studies mechanisms of central control of peripheral metabolism and how this is altered in metabolic disease. We employ integrated physiology approaches to deconstruct the role of the brain in orchestrating organ crosstalk such as nutrient flux between adipose tissue and the liver and its relevance in regulating insulin action.
We aim to elucidate the role of the sympathetic nervous system (SNS), adipose tissue lipolysis, lipotoxicity, glucose counter-regulation, and neuroinflammation in the pathophysiology of diabetes and obesity.
Brain insulin signalling in metabolic homeostasis and disease
Scherer T et al. Nat Rev Endocrinol. 2021 Aug;17(8):468-483. doi: 10.1038/s41574-021-00498-x. PubMed »
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis
Fischer K et al. Nature Medicine. 2017 May;23(5):623-630. doi: 10.1038/nm.4316. Epub 2017 Apr 17. PMID: 28414329. PubMed »
Brain insulin controls adipose tissue lipolysis and lipogenesis
Scherer T et al. 2011 Feb 2;13(2):183-94. doi: 10.1016/j.cmet.2011.01.008. PubMed »
Fat cells gobbling up norepinephrine?
Ryu V, Buettner C. PLoS Biology. 2019 Feb 7;17(2):e3000138. doi: 10.1371/journal.pbio.3000138. eCollection 2019 Feb. PMID: 30730909. PubMed »