Brain insulin signaling in metabolic homeostasis and disease
Scherer T, Sakamoto K, Buettner C. Nature Reviews Endocrinology. 2021 Aug;17(8):468-483. doi: 10.1038/s41574-021-00498-x. Epub 2021 Jun 9. PubMed »
Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis
Hackl MT, Fürnsinn C, Schuh CM, Krssak M, Carli F, Guerra S, Freudenthaler A, Baumgartner-Parzer S, Helbich TH, Luger A, Zeyda M, Gastaldelli A, Buettner C, Scherer T. Nature Communications. 2019 Jun 20;10(1):2717. doi: 10.1038/s41467-019-10684-1. PMID: 31222048. PubMed »
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis
Fischer K, Ruiz HH, Jhun K, Finan B, Oberlin DJ, van der Heide V, Kalinovich AV, Petrovic N, Wolf Y, Clemmensen C, Shin AC, Divanovic S, Brombacher F, Glasmacher E, Keipert S, Jastroch M, Nagler J, Schramm KW, Medrikova D, Collden G, Woods SC, Herzig S, Homann D, Jung S, Nedergaard J, Cannon B, Tschöp MH, Müller TD, Buettner C. Nature Medicine. 2017 May;23(5):623-630. doi: 10.1038/nm.4316. Epub 2017 Apr 17. PMID: 28414329. PubMed »
Fat cells gobbling up norepinephrine?
Ryu V, Buettner C. PLoS Biology. 2019 Feb 7;17(2):e3000138. doi: 10.1371/journal.pbio.3000138. eCollection 2019 Feb. PMID: 30730909. PubMed »
Beneficial metabolic role of β-arrestin-1 expressed by AgRP neurons
Pydi SP, Cui Z, He Z, Barella LF, Pham J, Cui Y, Oberlin DJ, Egritag HE, Urs N, Gavrilova O, Schwartz GJ, Buettner C, Williams KW, Wess J. Science Advances. 2020 Jun 3;6(23):eaaz1341. doi: 10.1126/sciadv.aaz1341. eCollection 2020 Jun. PMID: 32537493. PubMed »
Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action
Shin AC, Filatova N, Lindtner C, Chi T, Degann S, Oberlin D, Buettner C. Diabetes. 2017 Jun;66(6):1560-1571. doi: 10.2337/db16-1238. Epub 2017 Apr 6. PMID: 28385803. PubMed »
Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain
Scherer T, Lindtner C, O’Hare J, Hackl M, Zielinski E, Freudenthaler A, Baumgartner-Parzer S, Tödter K, Heeren J, Krššák M, Scheja L, Fürnsinn C, Buettner C. Diabetes. 2016 Jun;65(6):1511-20. doi: 10.2337/db15-1552. Epub 2016 Feb 9. PMID: 26861781. PubMed »
Brain insulin controls adipose tissue lipolysis and lipogenesis
Scherer T, O’Hare J, Diggs-Andrews K, Schweiger M, Cheng B, Lindtner C, Zielinski E, Vempati P, Su K, Dighe S, Milsom T, Puchowicz M, Scheja L, Zechner R, Fisher SJ, Previs SF, Buettner C. Cell Metabolism. 2011 Feb 2;13(2):183-94. doi: 10.1016/j.cmet.2011.01.008. PMID: 21284985. PubMed »
Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism
Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, Smith RD, Qian WJ, Lynch CJ, Newgard CB, Buettner C. Cell Metabolism. 2014 Nov 4;20(5):898-909. doi: 10.1016/j.cmet.2014.09.003. Epub 2014 Oct 9. PMID: 25307860. PubMed »
Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action
Lindtner C, Scherer T, Zielinski E, Filatova N, Fasshauer M, Tonks NK, Puchowicz M, Buettner C. Science Translational Medicine. 2013 Jan 30;5(170):170ra14. doi: 10.1126/scitranslmed.3005123. PMID: 23363978. PubMed »
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
Buettner C, Muse ED, Cheng A, Chen L, Scherer T, Pocai A, Su K, Cheng B, Li X, Harvey-White J, Schwartz GJ, Kunos G, Rossetti L, Buettner C. Nature Medicine. 2008 Jun;14(6):667-75. doi: 10.1038/nm1775. Epub 2008 Jun 1. PMID: 18516053. PubMed »